Smokeless tobacco damages DNA, key enzymes

WASHINGTON - Smokeless tobacco’s adverse effects are not just limited to the mouth, it can also damage the normal function of a key family of enzymes found in almost every organ in the body, according to a new research.

The enzymes play important roles in production of hormones, including
the sex hormones estrogen and testosterone; production of cholesterol and vitamin D; and help the body breakdown prescription drugs and potentially toxic substances.
Smokeless tobacco also damages genetic material in the liver, kidney and lungs.

Krishan Khanduja and colleagues note widespread recognition of smokeless tobacco’s harmful effects on the mouth, which include an increased risk of gum disease and oral cancer.

The potential carcinogens and other chemicals in chewing tobacco and other smokeless products are absorbed into the blood and travel throughout the body.
owever, scientists have little information on smokeless tobacco’s effects on other parts of the body.

To fill that knowledge gap, the scientists evaluated changes in enzymes and genetic material in laboratory rats using extracts of smokeless tobacco.

In addition to damage to the genetic material DNA, they found that smokeless tobacco extracts alter the function of the so-called CYP-450 family of enzymes.

“These products are used around the world but are most common in Northern Africa, Southeast Asia, and the Mediterranean region,” the study says.

“Most of the users seem to be unaware of the harmful health effects and, therefore, use smokeless tobacco to ‘treat’ toothaches, headaches, and stomachaches. This false impression only promotes tobacco use among youth. The use of smokeless tobacco and its new products is increasing not only among men but also among children, teenagers, women, and immigrants of South Asian origin and medical and dental students,” the study adds.

The study has been published in ACS’ monthly journal Chemical Research in Toxicology. (ANI)