Black raspberries ‘highly effective in preventing colorectal cancer’

WASHINGTON - A new study has suggested that eating black raspberries could reduce your risk of getting colon cancer.

Researchers from the University of Illinois at Chicago reported that compounds found in black raspberries are highly effective in preventing colorectal tumours in mice.

The study pointed out that supplements of the raspberries were associated with a 45 percent reduction in the incidence of tumours, and a 60 percent reduction in the number of tumours in a specific strain of mouse engineered to develop intestinal tumours.

Building on previous research that found black raspberries have antioxidant, anti-cancer, anti-neurodegenerative and anti-inflammatory properties, they looked at the fruit’s ability to prevent colon cancer.

“We saw the black raspberry as a natural product, very powerful, and easy to access,” said lead author Dr Wancai Yang, an assistant professor of pathology at the UIC College of Medicine.

The researchers used two strains of mice, Apc1638 and Muc2, which each have a specific gene knocked out, causing the mice to develop either intestinal tumours (in the case of Apc1638) or colitis in the case of Muc2.

Colitis is an inflammation of the large intestine that can contribute to the development of colorectal cancer.

Both mouse strains were randomised to be fed either a Western-style, high-risk diet (high in fat and low in calcium and vitamin D) or the same diet supplemented with 10 percent freeze-dried black raspberry powder for 12 weeks.

The researchers found that in both mouse strains the black raspberry-supplemented diet produced a broad range of protective effects in the intestine, colon and rectum and inhibited tumour formation.

In the Apc1638 mice, tumour incidence was reduced by 45 percent and the number of tumours by 60 percent.

The researchers found that black raspberries inhibited tumour development by suppressing a protein, known as beta-catenin, which binds to the APC gene.

In the Muc2 mice, tumour incidence and the number of tumours were both reduced by 50 percent, and black raspberries inhibited tumour development by reducing chronic inflammation associated with colitis.

Experts say because black raspberries also prevent inflammation, they may help with other conditions, like heart disease.

The researchers now hope to obtain funding to begin clinical trials in humans, said Yang, whose research focuses on the interactions of genetic and nutritional factors in the development of intestinal cancer and tumour prevention.

Colorectal cancer is the third most common cancer and the second leading cause of cancer-related death in both men and women in the US, according to the National Cancer Institute.

The findings are published in the November issue of Cancer Prevention Research. (ANI)