Stem cell-based therapy offers new hope for kidney disease patients
By ANIFriday, October 16, 2009
WASHINGTON - Researchers have suggested that several stem cell based therapies can help treat patients with Alport syndrome.
Most often occurring in boys, Alport syndrome causes progressive kidney disease leading to kidney failure at a young age. Patients may develop hearing loss and eye disease as well.
Although treatment can slow the progression of kidney disease, there is currently no cure for Alport syndrome.
“Our study opens up many considerations of how new therapies related to the use of stem cells can be devised for our kidney patients with chronic disease,” said Raghu Kalluri, from Harvard Medical School, Boston, MA.
Lead researcher Dr Valerie LeBleu, also of Harvard Medical School tested various types of cell-based therapy in mice genetically engineered to develop Alport syndrome.
The experiments have provide evidence that stem cell treatments could repair the kidney defects associated with Alport syndrome.
“We found that stem cells derived from adult bone marrow are equally useful as embryonic stem cells,” said Kalluri.
“This will make it easier to translate these scientific discoveries to a treatment protocol for patients with Alport syndrome,” Kalluri added.
Transplantation of bone marrow from unaffected animals significantly improved kidney function in mice in the late stages of disease. Importantly, the results suggested that the beneficial effects of bone marrow transplantation may be achieved without the need for radiation.
“Bone marrow transplant and blood transfusion protocols have already been approved for previous clinical use in patients with end-stage kidney disease and Alport syndrome,” said Kalluri.
“Therefore, clinical application of this procedure is quite feasible and may help our patients immediately.”
The study appears in the Journal of the American Society of Nephrology (JASN). (ANI)
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January 8, 2010: 12:42 am
Where can I purchase stem cell capsules for regeneration of tissues . I have developed Anterior Horn cell disease and for this , it is the best cure . |
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December 12, 2009: 3:46 am
This is really a good news. I have cousin who needs stem cell therapy and we continously flock the net to know what is latest so that we can guide him. I have also come across few remarkable companies that provide the support systems for such procedures. |
 Virgil Bryant |
November 30, 2009: 12:52 am
Hello, my name is Virgil bryant I am interested in finding out when there will be more clinical trials, and how are the clinical trial going that are being done. Thanks |
 ibrahim |
November 7, 2009: 4:48 am
I’m 45 years suffering from diabetic type 11 since 1990. it has become very serious problem effected on all my live and my family as well. The Creatnine reached today to 400 /L as you will see in the attached recent blood test reports. it will be highly appreciation to hear form you if you could help me with new stem cell treatment clinics to repair and improve the diabetic kidneys functions and reduce Creatnine to avoid the complete kidney failure : “please send me in details “ |
 neuro |
November 2, 2009: 3:22 am
*treat sensory neural hearing loss with adult autologous stem cells* |
Mr. S.N. Chawla