Drug researcher dies of apparent overdose; fellow scientist-boyfriend faces drug charges

By Ben Nuckols, AP
Wednesday, September 30, 2009

Drug researcher dies, boyfriend faces drug charges

BALTIMORE — A neuroscientist who studied the effects of drugs on the brain is dead of an apparent overdose and her live-in boyfriend, who did similar research, is facing drug charges, Baltimore police said Tuesday.

Carrie E. Johns, 29, who had a Ph.D. in physiology and pharmacology, died Sunday night, shortly after she injected herself with a solution containing the narcotic painkiller buprenorphine, according to charging documents.

Buprenorphine, known as bupe, is frequently used as a heroin substitute to treat recovering addicts. Johns’ boyfriend, Clinton B. McCracken, told police that he obtained the drug from an online pharmacy in the Philippines, the documents show.

“The irony there is that these were individuals who were highly trained in the area of pharmacology, and they were ordering illegal, unregulated drugs from another country for recreational use,” said police spokesman Anthony Guglielmi.

McCracken, a 32-year-old native of Canada, has not been charged in Johns’ death but faces several drug charges. Police said they found a variety of drugs in the couple’s row home blocks from the medical school, including nearly three dozen marijuana plants and indoor growing equipment.

McCracken is free on bail, according to the Baltimore state’s attorney’s office. He did not return a phone message.

Johns and McCracken were both postdoctoral research fellows in the anatomy and neurobiology department at the University of Medicine School of Medicine. They performed laboratory research and did not treat patients, the school said in a statement.

In a lengthy statement to police, McCracken said he had been buying drugs online and using them recreationally for the past few years. The drugs were shipped to the United States inside toys and trinkets, he said.

McCracken claimed that he received pills that contained buprenorphine, dissolved them in water and prepared a solution that Johns injected with a syringe, the documents show.

Johns immediately began having trouble breathing. She had a history of asthma, and McCracken gave her an inhaler, then called 911, the documents show. She later died at a hospital. McCracken told police he had planned to inject himself with the solution but did not.

“The defendant stated that he thought they could control the morphine and buprenorphine,” Officer Dawnyell Taylor wrote in the report. “He stated that no one ever got hurt using those drugs, it must have been the batch of pills that was bad.”

Bupe abuse is rare in the United States, said Dr. Donald Jasinski, chief of chemical dependency at Johns Hopkins Bayview Medical Center. Baltimore’s health department has attributed one overdose death to bupe in the last two years.

A massive dose of bupe would be required to cause respiratory failure, but intravenous use of opiates can sometimes trigger a reaction that causes fluid to build up in the lungs, Jasinski said. He said the tablets obtained by McCracken may have been contaminated with another substance or may not have contained bupe at all.

An autopsy is being conducted to determine the cause of death, said Guglielmi. He said federal investigators would likely question McCracken about how he obtained the drugs but that police believe John’s death was an accident.

McCracken and John received Ph.D.’s from Wake Forest University. John has published articles detailing the effects of cocaine, amphetamines and alcohol on the brains of mice and monkeys.

Discussion

Tim
September 30, 2009: 9:57 am

IMO- It is unlikely that Ms John died from buprenorphine overdose because buprenorphine has a ceiling to its effects that some experts say make it impossible for an otherwise healthy person to have a fatal overdose from the opioid effects of the buprenoirphine. Instead, other agents in the tablet or asthmatic reaction to the injection were responsible. With off-shore pharmacies there is no guarantee that the tablet contained any buprenorphine at all. generics available in other countries contain talc as a binder which is very dangerous when injected or inhaled.

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